Description
Stearda is an endogenous fatty acid dopamide that is inactive at TRPV1 and CB1 receptors at concentrations up to 5 µM and exhibits no inhibitory effects on AMT or FAAH (IC50 > 25 µM). However, stearda potentiates TRPV1-mediated effects of NADA in vitro and in vivo, and enhances effects on intracellular Ca2+ (EC50 lowered 3-fold) and nociception. It also inhibits arachidonate 5-lipoxygenase (IC50 = 16 nM)